In any case, the issues of an inclusion of the JAK2/STAT3 pathway tweak in the defensive impacts of PCr against DCM have not been accounted yet after we have reviewed the cardioprotective effect of PCr in vivo and in vitro hyperglycemia-prompted concentration on its impact on the JAK2/STAT3 signaling pathway. The gene discussed is STAT3; the disease is familial dilated cardiomyopathy.