CREB1 and ischemic stroke: Many studies have shown that TMP and its derivatives or compatibility with salvianic acid A/resveratrol possess functional cardioprotection/neuroprotection after myocardial ischemia-reperfusion/ischaemic stroke through interfering with PI3K/Akt/GSK3β, PGC1α/Nrf2, BDNF/Akt/CREB pathway, up-regulating Nrf-2 and HO-1 expression, maintaining Ca2+ homeostasis, and inhibiting inflammatory reaction, etc. [18–20, 50–52].