TMP and the prescriptions can also reverse multidrug resistance induced by Dox in breast cancer, bladder cancer, hepatocellular carcinoma through regulating the expression and function of P-gp, MRP2, MRP3, MRP5, MRP1, GST, Bcl-2, and TOPO-II, or directly enhance the anti-cancer effect of Dox [55–58]. The gene discussed is BCL2; the disease is cancer.