However, a recent study observed a decrease in the risk of melanoma and nonmelanoma skin cancer in vitiligo subject with the absence of melanin in vitiligo skin, which may be explained by the inverse relationship between the risk of vitiligo and skin cancers in the RALY-EIF252-ASIPAHCY-ITCH, IRF4, TYR, and MC1R genes [74–77]. This evidence concerns the gene IRF4 and vitiligo.