Ultimately, we found that two CpG sites of the HIF-1α promoter were hypomethylated (vitiligo vs. normal control: HIF-1α-8-40 0.67% (0.48%-0.88%) vs. 0.87% (0.75%-1.08%), p < 0.05, and HIF-1α-8-133 0.54% (0.48%-0.88%) vs. 0.75% (0.61%-0.89%), p < 0.01, respectively) in CD8+ T cells of vitiligo compared to normal controls (Figure 5(a)). This evidence concerns the gene HIF1A and vitiligo.