F2RL1 and vitiligo: To investigate the mechanisms of the overexpression of HIF-1α and F2RL1 in CD8+ T cells in vitiligo, the methylation status of 47 CG pairs in the HIF-1α gene promoter (from +737 to -175) and 30 CG pairs in the F2RL1 gene promoter (from +711 to -238) with respect to the transcriptional start site (TSS) was analyzed in vitiligo- and normal-CD8+ T cells from PBMCs by using MethylTarget (Supplemental ).