In the stepwise multivariate regression analysis, the association between Lp(a) levels and high-risk PCa remained significant (Q4 vs. Q1, HR = 2.890, 95% CI: 1.148-7.274, p = 0.024) after adjusting for confounding factors including age, body mass index, hypertension, diabetes, coronary artery disease, and lipid-lowering drugs. The gene discussed is LPA; the disease is Hypertension.