The eIF3D knockdown researches conducted in a series of cancer cell lines involving breast cancer [35], NSCLC [36], melanoma [37], acute myeloid leukaemia [38], and colon cancer [39] revealed that the deletion of eIF3D caused a significant reduction in cell proliferation and colony formation due to an arrest of cell cycle at G2/M phase, suggesting its key role in cell cycle control and apoptosis. This evidence concerns the gene EIF3D and melanoma.