Matrix metalloproteinases (MMPs) [14, 15], specific tissue metalloproteinase inhibitors (TIMPs) [16, 17], galectins (Gals) [17–20], and the transforming growth factor-beta (TGF-β) [21] are examples of molecules that have been studied in the context of Chagas disease in both experimental and human models. The gene discussed is TGFB1; the disease is Chagas disease.