TNF and rheumatoid arthritis: There have been reports that HS is mainly used to treat RA, confirming Modern Clinical Pharmacological Research [10] and HS probably reduces the level of immunoglobulin G and circulating immune complex (CIC) [46], making inhibitory effect on cellular immunity and humoral immunity [10], stimulating the proliferating function of T cells, improving the activity of IL-2, and inhibiting the activity of IL-1β and IL-6, also inhibiting the release of nitric Oxide and TNF-α [47].