TNF and rheumatoid arthritis: HS exerted treatment effects on RA by regulating 4 core targets (CSF2, IL1β, TNF, and IL-6), the 6 compounds (phytol, heptacosane, hexahydrofarnesyl acetone, vernolic acid, L-α-palmitin, and methyl icosanoate) of HS have good interaction with 5 or more targets (Table 2).