TNF and rheumatoid arthritis: For instance, 10 and more than 10 chemical components of HS can be combined with CSF2, IL1β, TNF, and IL6, which involved in 15 pathways such as rheumatoid arthritis, TNF signaling pathway, and cytokine-cytokine receptor interaction (Figure 7(b)).4 core genes entered into String database, a total of 4 nodes, number of edges of 6, and average node degree of 3, with PPI enrichment P value < 0.0225 (Figure 7(c)).