In this study, the protein expression of the GLUT4 and AMPK increased obviously after treatment with HD and metformin; this is not only consistent with previous research results but also indicates that HD has a similar mechanism to metformin in increasing the protein expression of the GLUT4 and AMPK to regulate the glucose in the treatment of T2DM. The gene discussed is SLC2A4; the disease is type 2 diabetes mellitus.