Moreover, another proinflammatory cytokine which was strikingly high secreted by GC-MSCs, interleukin-8 (IL-8), was reported to enhance the proliferation, migration, and proangiogenesis ability of GC cells partly by regulating the activation of Akt or Erk1/2 pathway, which also participated in immune regulation we would elucidate in the following tumor immunity part [54]. The gene discussed is CXCL8; the disease is neoplasm.