For instance, S100 Calcium Binding Protein A4 (S100A4) secreted by MSCs isolated from patient-derived hepatocellular carcinoma (HCC) tissues upregulated the expression of miR155 in HCC cells, promoting tumor invasion through the suppressor of cytokine signaling 1- (SOCS1-) MMP9 axis [31]. This evidence concerns the gene MMP9 and hepatocellular carcinoma.