CLU and posterior cortical atrophy: On the one hand, these results support early reports from our group [15, 16, 26] and agree with the finding that histone tails modification, including H3 pan-deacetylation and H3K27 trimethylation as well as CpG island hypermethylation at the CLU promoter contribute to the epigenetic repression of this gene both in human PCa cell lines and in the TRAMP model [17, 27].