TMPRSS2 and posterior cortical atrophy: Of note, p-p65S536 is increased in patients carrying TMPrSS2/ERG (T/E) fusion, the most common gene rearrangement in PCa, where it is suggested to play a critical role in PCa tumorigenesis by enhancing the p65 transcriptional activity of both proinflammatory chemokines and ECM-modifying enzymes, thus producing a tumor-permissive microenvironment [35].