Moreover, the degree of renal fibrosis which was considered to be a key indicator of worsening kidney function is also the core of DN high mortality [7], mainly due to the accumulation of extracellular matrix (ECM) proteins (e.g., collagen and fibronectin), as well as epithelial-to-mesenchymal transition (EMT) [8, 9]. Here, FN1 is linked to liver dysplastic nodule.