SERPINE1 and diabetic kidney disease: When Yu et al. [32] explored the association between miR-370 and diabetic nephropathy, their results showed that the expressions of miR-370, fibronectin, type I collagen (Col I), type IV collagen (Col IV), and plasminogen activator inhibitor-1 (PAI-1) increased in DN rats, and changes in the expression of these molecules affect the polymerization and degradation of ECM [33, 34].