FOXO3 and liver dysplastic nodule: Studies have also found that miR-877-3p and miR-15a-5p mediate fibrosis in DN, and they are differentially expressed in DN and DM patients, which may be related to the fact that miR-877-3p is involved in oxidative stress to cause renal tubular cell apoptosis or increase the phosphorylation and transcriptional inactivation of FoxO3a through the PI3K/Akt pathway, so as to accelerate the development of renal disease [84].