SRD5A2 and disorder of sexual differentiation: It has been suggested that an effective and sensitive means for diagnosing 46,XY DSD cases would include screening SRD5A2 gene mutations in cases with urinary Et/An ratios higher than 1.49 (or an An/Et ratio less than 0.67) [33], a much higher cutoff than our finding and therefore should lower the detection rate when applied to our series.