In addition, our findings showed exosomes containing EV71 RNA (EXO-EV71-RNA) circulated in encephalitis patients’ plasma, although EV71 could migrate to the brainstem via retrograde axonal transport [3] and prohibitin (PHB) was involved in the entry of EV71 virus into motoneuron cells, where EV71 could enter the CNS [4]. This evidence concerns the gene PHB1 and encephalitis.