Ultimately, 8 probands were diagnosed as hereditary leukodystrophies, including AARS2‐related adult‐onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) (proband 1), CSF1R‐related ALSP (probands 2 and 3), leukoencephalopathy with vanishing white matter (VWM) (proband 4), and Globoid cell leukodystrophy (GLD) (probands 5‐8). Here, AARS2 is linked to Leukoencephalopathy.