Similarly, by using cancer organoids, the researchers revealed that the cathepsin B led to the collective invasion in salivary adenoid cystic carcinoma [46], the inhibition of rho-associated protein kinase 2 (ROCK2) associated with initiating collective invasion in colorectal adenocarcinomas [47], and the loss of heat-shock factor 2 (HSF2) correlated with collective invasion in prostate cancer [48]. Here, ROCK2 is linked to Familial prostate cancer.