CRTC1 and Tachycardia: Here, we observed unique alternations of cardiac function in response to activation of TORC1 (via Tsc1 knockdown), including decreased heart period (Tachycardia, fast heart rate), and reduced diastolic intervals (Figures 4E, S6D,E) These cardiac functional changes are not the same as age-induced cardiomyopathies, rather they resemble high-fat-diet-induced cardiac complications where TORC1 is known to play an important role [12].