RHEB and cardiomyopathy: Similar cardiomyopathy phenotypes were also observed in other TORC1 activation mutants, such as 1) knockdown of REPTOR (Repressed by TOR), a recently identified bZIP transcription factor that is negatively regulated by TORC1 [37] (Figure S6G–I), and 2) overexpression of Rheb (Ras Homolog Enriched in Brain), a positive regulator of TORC1 (Figure S6J–L).