AGT and chronic obstructive pulmonary disease: In rats with angiotensin II–induced vascular injury and hypertension, it has been shown that mycophenolate mofetil prevents renal damage16 and interferon-γ targeting reduces cardiac arrhythmias and fibrosis without significant effects on blood pressure.26 As such, in patients with hypertension, anti-inflammatory therapy may provide benefit without blood pressure reduction.