Although Slc2a3+/− young mice (P21) exhibit a compensatory increase in GLUT1-mediated glucose into the brain and monocarboxylate transporter isoform 2-transported lactates into neurons, neuron-specific glucose deficiency caused by the decline in GLUT3 has a negative impact on neurodevelopment, including learning and memory impairment (Zhao et al. 2010). Here, SLC2A3 is linked to memory impairment.