A recent study using whole-exome sequencing identified mutations in the cyclin F gene, ccnf, in the relatives of patients with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) [195], which have a common pathological feature of aberrant accumulation of ubiquitinated transactive response (TAR) DNA-binding protein 43 (TDP-43) [196–198]. Here, TARDBP is linked to amyotrophic lateral sclerosis.