In a PD model induced by the treatment of 1-methyl-4-phenylpyridinium (MPP +), the expression of sestrin-2, an antioxidant protein, was increased by MPP + -induced p53 activation, and such enhanced expression of sestrin-2 protects cells against ROS, suggesting a novel role of p53 in PD [119]. Here, SESN2 is linked to Parkinson disease.