However, functionally compromised variants of p53 such as those with an altered tertiary structure (called unfolded p53 or conformational mutant p53) have been distinctly observed in AD patients [109, 110] and in older APPswe/PS1-A246E AD transgenic mice [111], but not in non-AD individuals, including PD patients [109]. The gene discussed is TP53; the disease is Parkinson disease.