PIN1 and Familial prostate cancer: In addition, several studies have demonstrated that small non-coding microRNAs (miRNAs), including miR-200b in breast tumor [206], miR-296-5p in prostate cancer [207], miR-874-3p [208] and miR-140-5p [209] in hepatocellular carcinoma, and miR-370 in esophageal squamous cell carcinoma [210], negatively regulate Pin1 expression (Fig. 4).