The secreted soluble neuroligin-3 can act as a mitogen for the glioma, inducing focal adhesion kinase (FAK), phosphoinositide 3-kinase (PI3K)-mTOR pathway, expression of neuroligin-3 and other synapse genes, leading to the proliferation of the glioma cells [276–278] (Fig. 5). Here, NLGN3 is linked to central nervous system cancer.