These markers including α-synuclein, ubiquitin as a marker of the proteasome system [33], 3-nitrotyrosine (3NT) as a marker of oxidative and glial fibrillary acidic protein (GFAP) have been implicated in dopamine neuron degeneration in PD, and have also showed age-related and region-specific changes [34]. Here, GFAP is linked to Parkinson disease.