In line with the above results, in cisplatin or LPS-induced AKI mice, we found that increased renal 8-iso-PGF-2α and 15-F2t-isoprostane production were concomitant with decreased activities of SOD, CAT and GSH in the kidneys, while these effects were again reversed by inhibition of salusin-β (Fig. 10G–I). Here, PPIB is linked to acute kidney injury.