Because we cannot exclude that BAP1 may also have additional roles that could be relevant in cancer progression (He et al., 2019), dissecting the contribution that vPRC1 forms play under pathological conditions of H2AK119ub1 deregulation will became a critical step for the future to define the tumor suppressive molecular properties of BAP1 and eventually uncover vulnerabilities for new strategies of intervention. The gene discussed is BAP1; the disease is cancer.