To date, CDK13-related disorder has been reported in 44 patients [17], and although there is a wide phenotypic heterogeneity [18], all patients are characterized with developmental delay (motor and speech domains) and variable craniofacial features (hypertelorism, flat midface, broad nasal bridge, small mouth, low-set ears); most show mild to moderate intellectual disability. Here, CDK13 is linked to Intellectual disability.