While it can retrospectively not be proven that these patients had indeed AQP4-IgG- or MOG-IgG-related NMO, Baillie’s report again demonstrate that the peculiar coexistence of optic and spinal symptoms that characterises NMO, i.e. the isolated affection of two sites not apparently connected in terms of anatomy or function, attracted the attention of physicians much earlier than previously thought. Here, MOG is linked to neuromyelitis optica.