The risk (major) allele (G) of the rs6677604 variant is a non-coding SNP located in intron 11 of CFH and has previously been described to increase susceptibility for age-related macular degeneration and IgA nephropathy and to decrease susceptibility for systemic lupus erythematosus [46–48]. The gene discussed is CFH; the disease is systemic lupus erythematosus.