In contrast, at 20 h after infection brain levels of IL-6 (19.30 vs. 6.76 ng/mg tissue, P = 0.004), IL-10 (0.88 vs. 0.27 ng/mg tissue, P = 0.013), MIP-2 (15.56 vs. 7.48 ng/mg tissue, P = 0.023) and KC (31.55 vs. 10.43 ng/mg tissue, P = 0.019) were increased in Cfh−/− mice compared to wt mice (Fig. 4c). Here, CFH is linked to infection.