We evaluated the role of FH in pneumococcal meningitis: first, we analyzed whether genetic variations in CFH in bacterial meningitis patients influenced disease severity, then measured FH in the cerebrospinal fluid (CSF) and performed immunohistochemistry staining for FH in brains of bacterial meningitis patients to determine if and where FH is expressed during meningitis. Here, FH is linked to pneumococcal meningitis.