In conclusion, we report that a liver biopsy can be considered representative for the remodeling occurring in the entire liver of Lepob/Lepob-NASH mice following pharmaceutical treatment, though changes are slightly different using an in-depth stereological assessment of the whole organ, as evidenced here for liraglutide and INT-767 for col1a1 assessments. The gene discussed is COL1A1; the disease is metabolic dysfunction-associated steatohepatitis.