The interaction between B7H5 and CD28H can promote the proliferation and cytokine production of T cells via the AKT pathway, while some studies confirmed that B7H5 could prevent the expression and secretion of cytokines by T cells to inhibit their response, including the IL‐5, IL‐10, IFNγ and TNFα.10 Therefore, the interaction of B7H5 and CD28H may inhibit the immune response as a co‐inhibitor in GC. This evidence concerns the gene TMIGD2 and gastric cancer.