Using human osteoclast progenitor cells isolated from patients with multiple myeloma as the experimental object, John D. Shaughnessy Jr found that the differentiation of human osteoclasts was inhibited by Wnt/β‐catenin pathway.36 Wnt cascade is initiated by the binding of Wnts to LRP/Fzd receptor complex, leading to the recruitment, phosphorylation and inactivation of GSK3β. The gene discussed is GSK3B; the disease is AL amyloidosis.