Similar to Batf, Blimp‐1 is upregulated in progressor patients with chronic HIV infection compared to non‐progressors that control HIV viral loads.33 Blimp‐1 expression in CD4 T cells mediates the production of IL‐10, which can further contribute to the dysfunctional state of exhausted T cells during chronic viral infection.34 Exhausted T cells may coexpression pairs of transcription factors including Blimp‐1 and Eomes, however, expression is not uniform where combinations of different factors may coexist. This evidence concerns the gene CD4 and HIV infectious disease.