Connexin43 (Cx43) is a protein that forms gap junction channels and hemichannels playing important roles in cellular communication.6 Cx43 interacts with a plethora of intracellular signaling partners,7 such as c-Src,8 which is a proto-oncogene that regulates a wide range of cellular events related to cancer.9–11 Indeed, in astrocytes, ectopic expression of v-Src, the active viral form of Src, promotes the development of astrocytomas.12 This evidence concerns the gene GJA1 and cancer.