However, connexins can also play pro-tumorigenic roles in glioma.25 Indeed, Cx46 is upregulated in GSCs and required for their maintenance.17 In addition, restoration of Cx43 in glioma cells can favor glioma invasion.26,27 These studies indicate that very specific Cx-related tools should be used to target glioma. This evidence concerns the gene GJA1 and central nervous system cancer.