AIF1 and colitis: We found that within the mPFC, DSS-induced colitis significantly decreased Iba-1 immunoreactivity both in the infralimbic cortex (ILC) (F(1, 23) = 4.4; p = 0.05) and in the cingulate cortex (CC) (F(1, 24) = 8.4; p = 0.008), attesting to a marked effect of experimental colitis on this brain region (Fig. 1; Fig. 2a,b).