We also detected a colitis-induced reduction of CD68 immunoreactivity in the hippocampal CA1 region (F(1, 24) = 6.799; p = 0.015; Fig. 4) and a trend towards reduced CD68 immunoreactivity in the DG (F(1, 25) = 3.781; p = 0.063), but not in the hippocampal CA3 region, again similar to the Iba-1 results (Fig. 3d–f). Here, AIF1 is linked to colitis.