TIMP2 and cancer: To do this, we first identified a list of 334 genes of interest (GOI) consisting of 300 genes that consistently display a positive correlation with TIMP2 across all cancers types, plus 34 genes we identified as TIMP2 interacting partners, such as the metzincin proteases (MMPs and ADAM12), as well as putative TIMP2 binding partners LRP1/2, extracellular Src kinase, integrin α3β1, and IGFR1 (listed in Supplementary Table IV).