ADAM12 and lung carcinoma: In order to more clearly understand the significance of TIMP2 expression levels in breast and lung carcinomas, we assessed the levels of TIMP2 in relation to metzincin targets (MMPs and ADAM12) by simple division of the TIMP2 RPKM (Reads Per Kilobase of transcript, per Million mapped reads) by that of MMPs and ADAM12 (sum of the MMP family and ADAM12 RPKM).