ABCC2 and Dubin-Johnson syndrome: An absence of functional MRP2 from the canalicular membrane is associated with conjugated hyperbilirubinemia and ‘dark pigment’ deposition in hepatocytes in the hereditary ABCC2 deficiency Dubin-Johnson syndrome (DJS)78,79, Eisai hyperbilirubinemic rats80,81 and knockout mouse strains82.