Importantly, we observed a significant increase in caspase 3/7 activity during infection with rZIKV-Paraiba or rZIKV-RGN as compared with rZIKV-Paraiba NS2A A117V or rZIKV-RGN NS2A A117V, respectively, at early times post-infection (Fig. 6D). The gene discussed is CASP3; the disease is infection.