Indeed, it is that mutations of the KCTD protein SHKBP1 are linked to acute myeloid leukemia and that the haploinsufficiency of KCNRG could be associated with the progression of chronic lymphoid leukemia, although no direct connections between KCTD proteins and this pathological state have been so far reported. The gene discussed is KCNRG; the disease is acute myeloid leukemia.