Morphological variants of DAC, which is located adjacent to Gleason pattern 4 DACs, also showed expression of HoxB13 in columnar cells of Gleason pattern 3 DACs (Fig. 3D) and singly scattered tumor cells or those comprising large nests with central comedo-type necrosis of Gleason pattern 5 DACs (Fig. 3E). This evidence concerns the gene HOXB13 and neoplasm.