Univariate analysis identified the following characteristics that were associated with shorter BCR-free survival: DAC (P < 0.001), higher Gleason score (P < 0.001), bilateral location (P = 0.032), tumor volume more than 5 cc (P < 0.001), presence of EPE (P < 0.001), presence of LVI (P = 0.001), extension to resection margin (P < 0.001), involvement of seminal vesicles and/or lymph node metastasis (P < 0.001), and high level of HoxB13 expression (P < 0.001). This evidence concerns the gene HOXB13 and neoplasm.