In the training set, DAC was significantly associated with a higher Gleason score (P < 0.001), tumor volume more than 5cc (P = 0.004), presence of extraprostatic extension (EPE; P = 0.004), advanced pathologic T stage (P = 0.016), intact PTEN expression (P < 0.001) and occurrence of biochemical recurrence (BCR; P = 0.004). This evidence concerns the gene PTEN and neoplasm.