In the training set, high level of HoxB13 expression was significantly associated with DAC (P < 0.001), a higher Gleason score (P < 0.001), tumor volume more than 5cc (P = 0.042), presence of EPE (P = 0.001), advanced pathologic T stage (P = 0.010), intact PTEN expression (P < 0.001) and occurrence of BCR (P < 0.001). The gene discussed is HOXB13; the disease is neoplasm.