The detection of elevated natriuretic peptides through B-type natriuretic peptide (BNP) and its propeptide N-type proBNP (NT-proBNP) has entered clinical use in diagnosing and guiding management of patients with or at risk for heart failure, and for risk prognostication in patients with chronic heart failure per guideline recommendations6,8. This evidence concerns the gene NPPB and congestive heart failure.