Compared to the c-Cbl+/+ mice (750 + 141.14 mm3), MC38 xenografts in c-Cbl+/− mice showed a higher growth of the tumor and had double volume (average + SD 1290 + 251.9 mm3, p = 0.003) by the end of 4 weeks (Fig. 1A–D). Here, CBL is linked to neoplasm.