CBL and neoplasm: Using isotype antibody (serving as a control) and GFP+ MC38 tumor lines, at 37 °C, the Cbl+/− macrophages showed a significant reduction in phagocytosis (7.63 + 0.14%) compared to Cbl+/+ macrophages (12.95 + 1.68%, p = 0.013) (Fig. 3B).