Interestingly, we observed that TDP-43 inclusions within micronuclei co-aggregated with endogenous RGNEF (Fig. 4C), but not with FUS/TLS (Fig. 4D), or sirtuin 1, a protein that is not associated with ALS (Fig. 4E). This evidence concerns the gene SIRT1 and amyotrophic lateral sclerosis.