BACE1 and Alzheimer disease: In our model ~50% to ~70% BACE1 protein reduction resulted in an ~50% decrease of Aβx-40 in cortex and hippocampus, it remains to be determined if this reduction in Aβ would be enough to reverse amyloid plaque deposition, this can be achieved by crossing BACE1 cKO mice with murine models of AD or chronically administering a BACE inhibitor at ≤ED50.