Extracellular regulated kinase 1/2 (ERK1/2) and the ERK-dependent phosphorylation site of p70-S6K (pp70-S6KThr421/Ser424) did not show altered phosphorylation after 3 weeks of OM stimulation without or with Rapa (Fig. 3G,H). This evidence concerns the gene MAPK3 and ocular melanoma.