Given the previous findings that Eed loss promoted lung adenocarcinoma progression and was associated with poor prognosis in KRasG12D/+; Trp53fl/fl, but not in KRasG12D/+ mice, and the potential regulation of PRC2 by ONECUT2 revealed by our study, we believe ONECUT2 is one of the genetic programs that confer PRC2 tumor-suppressive roles in RAS-driven lung cancer. The gene discussed is ONECUT2; the disease is lung adenocarcinoma.