Given the significant overlap of genes upregulated by Eed loss in the context of Kras activation and Trp53 inactivation and genes upregulated by ONECUT2 overexpression in A549 cells, we speculate that ONECUT2 overexpression induces aberrant mucinous differentiation, which, in combination with KRAS and TP53 mutations, promotes aggressive behaviors of lung adenocarcinoma. Here, KRAS is linked to lung adenocarcinoma.