Microarray profiling indicates that DST is downregulated in the mammary epithelial cell line MCF10A with conditional Src induction (MCF10A-ER-Src), in Estrogen receptor (ER)-positive ductal carcinoma in situ (DCIS) and in invasive ductal carcinoma (IDC), irrespective of the ER status33,34. The gene discussed is ESR1; the disease is ductal breast carcinoma in situ.