Within the right ventricle, collagen deposition was significantly lower in both statin-treated cohorts compared to SIV-PAH+ animals (Fig. 5a; SIV/Statin Group 2, P < 0.0001; SIV/Statin Group 3, P < 0.0001), and did not correlate with increased peak pulmonary pressures (Fig. 5b, center and right panels). The gene discussed is EEF1A2; the disease is pulmonary arterial hypertension.