In the alcohol consumption-stratified analysis, the minor allele of GCK (rs758989) and the major allele of INSR (rs7245757, rs1035942, rs1035940, and rs2042901) had a tendency to increase the incidence of diabetes in the chronic heavy drinkers; however, there were no significant genotype-related differences in the never-drinkers (Supplementary Table S6). Here, GCK is linked to diabetes mellitus.