Because of the small sample number of GCK and INSR homozygous minor genotype carriers with the incidence of diabetes, the analysis according to genotype was performed using the dominant model for GCK and the haplotype model for INSR. The aggravating effects of the chronic heavy alcohol consumption on the incidence of diabetes were only present in the C allele of GCK (Table 2). This evidence concerns the gene INSR and diabetes mellitus.