Although several NGS studies of patients with BC and/or OC have identified LPVs/PVs in the MMR genes9,12–14,17,23, we did not identify pathogenic variants in MLH1, MSH2, MSH6 or PMS2. We identified the MLH1 c.[-28A>G; -7C>T] in three patients. The gene discussed is PMS2; the disease is breast cancer.