The results suggested a significantly elevated exploration activity and unconditioned anxiety-related behavior in Fmr1 KO mice, which was reversed by DG ICAM5 knockdown for total travel distance (Fig. 6A; 38 ± 3.6%, p = 0.0032), center distance (Fig. 6B; 24 ± 2.1%, p = 0.0455), out-of-center distance (Fig. 6C; 21%, p = 0.0365), and times across the edges (Fig. 6D; 57 ± 4.4%, p = 0.0024). The gene discussed is ICAM5; the disease is Anxiety.