As reported by many research groups, Fmr1 KO mice exhibited impaired memory and exploratory and anxiety-like behaviors (Spencer et al., 2005; Baker et al., 2010), which were ameliorated to some degree by lowering ICAM5 expression in DG, a pivotal area connecting amygdala and prefrontal cortex (Zancada-Menendez et al., 2017). Here, ICAM5 is linked to Anxiety.