We present here the first evidence that the neuroinflammatory mediator IL-1β facilitates ubiquitin ligase parkin/NEDD8 interactions as it: (i) elevates the steady-state levels of parkin and phosphorylated parkin; (ii) induces nuclear-to-cytoplasmic translocation of NEDD8; and (iii) induces NEDD8-parkin ligation in the cytoplasm of hippocampal pyramidal neurons in AD. Here, NEDD8 is linked to Alzheimer disease.